Increased expression of SCARF genes favoring SARS-CoV-2 infection in key target organs in CKD

Abstract Background Chronic kidney disease (CKD), especially diabetic CKD, is the condition that most increases risk of lethal coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS‑CoV‑2). However, underlying molecular mechanisms are unclear. SARS-CoV-2 and coronavirus-associated receptors factors (SCARFs) regulate cell entry and/or replication. We hypothesized CKD may alter expression SCARF genes. Methods A literature search identified 34 genes which we selected 21 involved in interactions between SARS-CoV/SARS-CoV-2 host cells assessed their mRNA target tissues COVID-19 (kidneys, lungs, aorta, heart) mice with adenine-induced CKD. Results Twenty were differentially expressed at least one organ For 15 genes, differential would be expected to favor infection severity. Of these 13 8 validated human transcriptomics datasets, including those for common cause nephropathy. Two reported protect from downregulated two non-kidney organs: Ifitm3 encoding interferon induced transmembrane protein 3 (IFITM3) lung Ly6e lymphocyte antigen 6 family member (LY6E) aorta. Conclusion associated multiple organs COVID-19, some sensitize infection. This information facilitate developing therapeutic strategies aimed decreasing severity patients